Robert V Farese Selected Research

PKC-3 protein

3/2021	Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus.
1/2018	Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
1/2017	Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
11/2015	BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.
1/2015	Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
7/2014	Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
1/2014	Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.
11/2013	Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
6/2012	Atypical protein kinase C in cardiometabolic abnormalities.
6/2009	The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

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Robert V Farese Research Topics

Disease

41	Insulin Resistance 01/2018 - 04/2002
35	Obesity 01/2022 - 04/2002
17	Type 2 Diabetes Mellitus (MODY) 01/2022 - 02/2002
13	Hyperinsulinism (Hyperinsulinemia) 03/2021 - 04/2006
13	Frontotemporal Dementia (Semantic Dementia) 01/2018 - 05/2010
12	Glucose Intolerance 11/2020 - 06/2003
10	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2017 - 01/2004
8	Inflammation (Inflammations) 12/2019 - 12/2009
7	Hyperlipidemias (Hyperlipidemia) 03/2021 - 06/2009
6	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 12/2020 - 03/2011
6	Metabolic Diseases (Metabolic Disease) 01/2020 - 04/2009
5	Atherosclerosis 01/2022 - 02/2003
4	Fatty Liver 06/2014 - 09/2008
4	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2013 - 05/2010
4	Neoplasms (Cancer) 08/2013 - 08/2005
4	Hypertriglyceridemia 06/2012 - 06/2009
4	Abdominal Obesity 06/2012 - 08/2007
3	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 10/2014
3	Non-alcoholic Fatty Liver Disease 12/2019 - 08/2009
3	Body Weight (Weight, Body) 12/2014 - 11/2004
3	Neuroinflammatory Diseases 05/2013 - 11/2012
3	Hypercholesterolemia 06/2012 - 04/2012
2	Fibrosis (Cirrhosis) 12/2019 - 08/2009
2	Leukemia 01/2019 - 01/2016
2	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 09/2009
2	Starvation 01/2018 - 05/2013
2	Heart Failure 10/2014 - 03/2003
2	Thinness 01/2014 - 01/2012
2	Infections 04/2013 - 11/2010
2	Alopecia (Baldness) 02/2009 - 01/2002
1	Motor Neuron Disease (Primary Lateral Sclerosis) 12/2020
1	Atrophy 12/2020
1	TDP-43 Proteinopathies 12/2020
1	Liver Failure 12/2019
1	Parkinson Disease (Parkinson's Disease) 01/2019
1	Vascular Diseases (Vascular Disease) 01/2019
1	Paraplegia (Spastic Paraplegia) 02/2018
1	Hereditary Spastic Paraplegia 02/2018
1	Hepatitis 06/2017
1	Liver Diseases (Liver Disease) 06/2017
1	Prostatic Neoplasms (Prostate Cancer) 01/2017
1	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2017
1	Weight Gain 01/2017

Drug/Important Bio-Agent (IBA)

32	Insulin (Novolin)FDA Link 03/2021 - 02/2002
31	LipidsIBA 01/2022 - 01/2002
30	Glucose (Dextrose)FDA LinkGeneric 03/2021 - 02/2002
24	Triglycerides (Triacylglycerol)IBA 01/2020 - 11/2002
20	EnzymesIBA 03/2021 - 01/2003
18	ProgranulinsIBA 12/2020 - 05/2010
12	PKC-3 proteinIBA 03/2021 - 01/2004
12	Acyl Coenzyme A (Acyl CoA)IBA 12/2019 - 08/2002
12	Diacylglycerol O-AcyltransferaseIBA 12/2019 - 08/2002
11	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2006
7	Fatty Acids (Saturated Fatty Acids)IBA 12/2019 - 07/2002
6	LeptinIBA 01/2017 - 04/2002
5	CholesterolIBA 12/2019 - 02/2003
4	Insulin ReceptorIBA 11/2015 - 02/2003
4	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2015 - 01/2004
4	Protein Kinases (Protein Kinase)IBA 07/2014 - 06/2004
4	Phosphotransferases (Kinase)IBA 06/2012 - 06/2009
3	Sterol Regulatory Element Binding Protein 1IBA 01/2018 - 06/2009
3	Protein Kinase CIBA 01/2017 - 01/2004
3	Glycoproteins (Glycoprotein)IBA 05/2013 - 05/2010
3	AdiponectinIBA 01/2011 - 06/2003
3	protein kinase C lambdaIBA 06/2009 - 06/2004
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 06/2009 - 01/2004
2	Amyloid (Amyloid Fibrils)IBA 01/2021 - 10/2014
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 12/2020 - 09/2014
2	PalmitatesIBA 01/2019 - 01/2018
2	Serine (L-Serine)FDA Link 02/2018 - 06/2004
2	HydrolasesIBA 02/2018 - 01/2017
2	Lipase (Acid Lipase)FDA Link 02/2018 - 05/2006
2	Cholesterol Esters (Cholesteryl Esters)IBA 01/2017 - 02/2003
2	CeramidesIBA 11/2015 - 01/2015
2	Pharmaceutical PreparationsIBA 04/2013 - 05/2011
2	Antisense OligonucleotidesIBA 06/2012 - 08/2009
2	Messenger RNA (mRNA)IBA 06/2012 - 12/2003
2	Dietary CholesterolIBA 06/2012 - 11/2004
2	CarbohydratesIBA 04/2012 - 03/2010
2	DiglyceridesIBA 08/2011 - 11/2010
2	Lipoproteins (Lipoprotein)IBA 11/2004 - 02/2003
2	protein kinase C zetaIBA 08/2003 - 10/2002
1	ReninIBA 03/2021
1	SodiumIBA 03/2021
1	AngiotensinsIBA 03/2021
1	Peptides (Polypeptides)IBA 01/2021
1	FructoseIBA 12/2019
1	UbiquitinIBA 01/2019
1	Ligases (Synthetase)IBA 01/2019
1	SynucleinsIBA 01/2019
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	ProteomeIBA 01/2018
1	Sterol Esterase (Hormone-Sensitive Lipase)IBA 01/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	MelanocortinsIBA 01/2017
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2017
1	Complement System Proteins (Complement)IBA 05/2016
1	TOR Serine-Threonine KinasesIBA 01/2015

Therapy/Procedure

4	Therapeutics 12/2019 - 02/2003